Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
In conclusion, insulin resistance correlates with the deterioration of glucose tolerance and contributes to the hyperglycaemia of glucokinase-deficient diabetes.
|
8720607 |
1996 |
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
One form of maturity-onset diabetes of the young, MODY3, is characterized by a severe insulin secretory defect, compared with MODY2, a glucokinase-deficient diabetes.
|
9313763 |
1997 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The family members of the patients affected with GCK mutation were also examined.Two of the 58 PTDM patients (3.4%) were found to have GCK mutations.
|
11106831 |
2000 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Unusual causes of diabetes have been identified, including autosomal dominant, single gene forms due to mutations of glucokinase, the hepatocyte nuclear factors, and insulin promoter factor 1.
|
11467342 |
2000 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Unlike in MODY2, which is a nonprogressive form of diabetes, mitochondrial diabetes does show a pronounced age-dependent deterioration of pancreatic function indicating involvement of additional processes.
|
14749274 |
2004 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Our cohort included 46 diabetic HNF1A gene mutation carriers, 55 type 2 diabetes (T2DM) subjects, 42 type 1 diabetes (T1DM) patients, and 31 glucokinase (GCK) gene mutation carriers with diabetes as well as 51 healthy controls.
|
25987348 |
2015 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
DNA was isolated from lymphocytes, and DNA polymorphisms in the glucokinase gene were tested for linkage with diabetes.
|
8433729 |
1993 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The glucokinase and mitochondrial tRNA(Leu(UUR)) genes were screened for mutations in at least one affected subject from each family in order to assess the contribution of mutations in these genes to the development of the diabetes.
|
7542040 |
1995 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Molecular analysis by PCR sequencing of the promoter, the 5' untranslated region (UTR) and exons of both GCK and HNF1A genes was carried out in two families with clinically diagnosed dominant diabetes mellitus.
|
23009393 |
2013 |
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
Thus, the widely used approach to nonspecifically activate β-cell and hepatic GCK to treat diabetes mellitus is therefore questionable and may cause serious side effects.
|
21490074 |
2011 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Biochemical genetic studies have characterized many activating and inactivating GK mutants that have been discovered in patients with hyperinsulinemic hypoglycemia or diabetes, all inherited as autosomal dominant traits.
|
12475782 |
2002 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Variation at the rs560887 locus of G6PC2 is associated with worse glycated haemoglobin levels in individuals with GCK mutations; GG homozygotes are more likely to meet diagnostic criteria for diabetes based on HbA(1c) level.
|
22486180 |
2012 |
Diabetes Mellitus
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Glucokinase (GK) is an important enzyme for regulating blood glucose levels and a potentially attractive target for diabetes of the young type 2 and persistent hyperinsulinemic hypoglycemia of infancy.
|
16938872 |
2006 |
Diabetes Mellitus
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Glucokinase (GK) plays a vital role in the control of blood glucose levels and its altered activity can lead to the development of forms of diabetes.
|
30087826 |
2018 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants.
|
8325892 |
1993 |
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
Clinical information and blood for GCK gene analysis were obtained from grandparents with diabetes.
|
29510678 |
2018 |
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
The glucokinase exons were sequenced in patients with diabetes.
|
30245511 |
2019 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In the absence of a crystal structure for glucokinase, our models help rationalize the potential effects of mutations in diabetes and hypoglycemia, and the models may also facilitate the discovery of pharmacological glucokinase activators and inhibitors.
|
10480597 |
1999 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We aimed to derive age-related HbA1c reference ranges for these patients to determine how well HbA1c can discriminate patients with a GCK mutation from unaffected family members and young-onset type 1 (T1D) and type 2 diabetes (T2D) and to investigate the proportion of GCK mutation carriers diagnosed with diabetes using HbA1c and/or FPG diagnostic criteria.
|
23799006 |
2013 |
Diabetes Mellitus
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes.
|
30146176 |
2018 |
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
These clinical indicators could be used as markers of MODY2 and MODY3 in young patients with diabetes.
|
31214998 |
2019 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
LHGDN |
Permanent neonatal diabetes mellitus caused by a novel homozygous (T168A) glucokinase (GCK) mutation: initial response to oral sulphonylurea therapy.
|
18571549 |
2008 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
GCK-MODY carriers were found in a frequency of 3% among 1043 diabetes mellitus (DM) patients and constituted the second most numerous group of DM patients, following type 1 DM, in our centre.
|
28663157 |
2017 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Over a three-year period, 72 pregnant women with recently diagnosed diabetes mellitus were prospectively assessed for presence of the most common pathogenic GCK mutations.
|
25012807 |
2015 |
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
iPSC-derived β cells model diabetes due to glucokinase deficiency.
|
23778137 |
2013 |